基于人群的一系列患有骨肉瘤和软组织肉瘤的年轻成年人母亲中的恶性疾病。
Malignant disease in the mothers of a population-based series of young adults with bone and soft tissue sarcomas.
作者信息
Hartley A L, Birch J M, Blair V
机构信息
Cancer Research Campaign, Christie Hospital and Holt Radium Institute, Manchester, UK.
出版信息
Br J Cancer. 1991 Mar;63(3):416-9. doi: 10.1038/bjc.1991.96.
Mothers of a population-based series of young adults with bone and soft tissue sarcoma were traced and their cancer risks estimated. No overall excess of cancers compared with expected numbers calculated from population rates was seen but mothers of patients with synovial sarcoma had significantly more cancers than expected and this was accounted for mainly by an excess of breast cancer. In addition there were strong indications that a proportion of cases were members of families with inherited cancer-prone syndromes, in particular with neurofibromatosis or with the Li Fraumeni cancer family syndrome.
对一系列以人群为基础的骨肉瘤和软组织肉瘤青年患者的母亲进行了追踪，并估计了她们患癌的风险。与根据人群发病率计算出的预期数量相比，未发现总体癌症超额情况，但滑膜肉瘤患者的母亲患癌数量明显多于预期，这主要是由于乳腺癌超额所致。此外，有强烈迹象表明，一部分病例是具有遗传性癌症易患综合征家族的成员，特别是患有神经纤维瘤病或李-弗劳梅尼癌症家族综合征的家族。
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