骨肉瘤和软骨肉瘤患儿母亲患乳腺癌的风险。
Breast cancer risk in mothers of children with osteosarcoma and chondrosarcoma.
作者信息
Hartley A L, Birch J M, Marsden H B, Harris M
出版信息
Br J Cancer. 1986 Nov;54(5):819-23. doi: 10.1038/bjc.1986.245.
Abstract
Mothers of a population-based series of 86 children with osteosarcoma or chondrosarcoma were traced and their health status or cause of death ascertained. There were 6 cases of breast cancer among these mothers and 6 other cancers. Risk of breast cancer was approximately three times that expected, and appeared to be highest in mothers of boys and in mothers of children under the median age at diagnosis. The mothers who developed breast cancer were relatively young at diagnosis compared with population data. Risk of other malignancies in the mothers was not in excess of expectation. These findings are in line with those reported for breast cancer risk in mothers of children with soft tissue sarcomas, and provide further indications of a genetic component in the aetiology of these cancers.
摘要
对一组基于人群的86例骨肉瘤或软骨肉瘤患儿的母亲进行了追踪，并确定了她们的健康状况或死因。这些母亲中有6例患乳腺癌，还有6例患其他癌症。乳腺癌风险约为预期的三倍，且在男孩的母亲以及诊断时年龄低于中位数的患儿的母亲中似乎最高。与人群数据相比，患乳腺癌的母亲在诊断时相对年轻。母亲中其他恶性肿瘤的风险并未超过预期。这些发现与软组织肉瘤患儿母亲乳腺癌风险的报道一致，并进一步表明这些癌症的病因中有遗传因素。
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