Hartley A L, Birch J M, Blair V, Kelsey A M, Morris Jones P H
CRC Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, UK.
Int J Cancer. 1994 Mar 1;56(5):646-9. doi: 10.1002/ijc.2910560507.
Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families (Li-Fraumeni syndrome or neurofibromatosis). Reproductive loss was not related to index histology (miscarriages, p = 0.3; all losses, p = 0.6) but was significantly higher in "genetic" rather than "sporadic" families (miscarriages, p = 0.02; all losses, p = 0.01). However, excess reproductive loss was not a feature of families with the Li-Fraumeni syndrome, but appeared to be concentrated in the families affected by neurofibromatosis.
