Department of Pathology and Laboratory Medicine, National Defense Medical College, National Defense Medical College Hospital, Tokorozawa, Japan.
BJU Int. 2010 Sep;106(6):873-8. doi: 10.1111/j.1464-410X.2009.09144.x. Epub 2009 Dec 18.
To examine glucose-regulated protein 78 (GRP78; a major molecular chaperone at the endoplasmic reticulum, strongly expressed in several tumours) expression in urothelial carcinoma (UC) of the upper urinary tract (UUT) and to evaluate the diagnostic and progressive importance of GRP78 expression in UC-UUT.
We investigated GRP78 expression (using immunohistochemistry) in 126 UC-UUTs to assess its relevance to progression. GRP78 overexpression was recognised in 23 (18.3%) of tumour samples.
There was no association between GRP78 overexpression and clinicopathological findings, except for an association with low grade in invasive tumours. GRP78 overexpression significantly improved the disease-free survival rate in all patients (according to univariate and multivariate analyses), but did not alter the overall survival rate.
The detection of GRP78 overexpression would appear to provide valuable information for the prognosis of UC-UUT.
检测葡萄糖调节蛋白 78（GRP78；内质网的主要分子伴侣，在几种肿瘤中强烈表达）在上尿路尿路上皮癌（UC-UUT）中的表达，并评估 GRP78 表达在 UC-UUT 中的诊断和进展意义。
我们通过免疫组织化学检测了 126 例 UC-UUT 中 GRP78 的表达，以评估其与进展的相关性。在 23 例（18.3%）肿瘤样本中发现 GRP78 过表达。
除了与浸润性肿瘤的低级别相关外，GRP78 过表达与临床病理特征之间没有关联。GRP78 过表达显著提高了所有患者的无病生存率（根据单因素和多因素分析），但未改变总生存率。
GRP78 过表达的检测似乎为 UC-UUT 的预后提供了有价值的信息。
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