School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China.
J Biomater Sci Polym Ed. 2010;21(1):1-15. doi: 10.1163/156856209X410111.
In order to develop a new type of pressure-sensitive adhesive (PSA) for a transdermal drug-delivery system (TDDS), a quaternary blend (PDGW) composed of poly(N-vinyl pyrrolidone) (PVP), D,L-lactic acid oligomer (DLLAO), glycerol and water was prepared, in which glycerol and water were used as plasticizer. The effects of the number-average molecular weight (M(n)) of DLLAO and the contents of DLLAO and plasticizer on the PSA properties were studied. The results suggest that PDGW exhibits excellent PSA properties when M(n) of DLLAO is in the range of about 200-400 and the contents of DLLAO, glycerol and water are in the range of 5-20, 15-25 and 20-35 wt%, respectively. The miscibility between PVP and DLLAO was investigated via DSC, TGA and FT-IR, and all results indicate that PVP has good miscibility with DLLAO due to strong hydrogen-bond interaction. The storage stability of PDGW also was studied and the results show that the PDGW matrix possesses stable properties over time. In addition, in vivo skin irritation of PDGW was investigated using rabbit as model animal, and the results show that the PDGW does not cause irritation to skin after topical application for 120 h. Therefore, the PDGW possesses excellent PSA properties and presents potential application in TDDS.
为了开发一种用于透皮给药系统（TDDS）的新型压敏胶（PSA），我们制备了一种由聚（N-乙烯基吡咯烷酮）（PVP）、D,L-乳酸低聚物（DLLAO）、甘油和水组成的四元共混物（PDGW），其中甘油和水被用作增塑剂。研究了 DLLAO 的数均分子量（M(n)）和 DLLAO 及增塑剂含量对 PSA 性能的影响。结果表明，当 DLLAO 的 M(n)在 200-400 范围内，DLLAO、甘油和水的含量分别在 5-20、15-25 和 20-35wt%范围内时，PDGW 表现出优异的 PSA 性能。通过 DSC、TGA 和 FT-IR 研究了 PVP 和 DLLAO 之间的混溶性，所有结果均表明 PVP 与 DLLAO 具有良好的混溶性，这是由于氢键相互作用较强。还研究了 PDGW 的储存稳定性，结果表明 PDGW 基质随时间具有稳定的性质。此外，还以兔为模型动物研究了 PDGW 的体内皮肤刺激性，结果表明 PDGW 在经皮应用 120 小时后不会引起皮肤刺激。因此，PDGW 具有优异的 PSA 性能，在 TDDS 中有潜在的应用前景。
