Crook M, Machin S, Crawford N
Department of Clinical Chemistry, Guy's Hospital, London.
Br J Haematol. 1991 Feb;77(2):209-14. doi: 10.1111/j.1365-2141.1991.tb07979.x.
Continuous flow electrophoresis has been used to investigate heterogeneity in the circulating platelets from patients with idiopathic thrombocytopenia (ITP) and from age- and sex-matched control donors. The ITP patients' platelet counts ranged from 15 to 80 X 10(9)/l and they had much higher mean volumes and significantly higher (two-fold) total cell and neuraminidase-labile surface sialic acid contents expressed per unit cell than normal. After volume normalization the mean difference between the two groups was not statistically significant. The relationships of these findings to abnormal thrombopoiesis and to molecular recognition for reticuloendothelial system (RES) removal are discussed.
连续流动电泳已被用于研究特发性血小板减少性紫癜（ITP）患者以及年龄和性别匹配的对照供者循环血小板的异质性。ITP患者的血小板计数范围为15至80×10⁹/L，他们的平均体积更高，并且每单位细胞表达的总细胞和神经氨酸酶不稳定表面唾液酸含量显著更高（两倍）。体积标准化后，两组之间的平均差异无统计学意义。讨论了这些发现与异常血小板生成以及网状内皮系统（RES）清除的分子识别之间的关系。
