GWAF：用于家族数据全基因组关联分析的 R 包。
GWAF: an R package for genome-wide association analyses with family data.
机构信息
Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Bioinformatics. 2010 Feb 15;26(4):580-1. doi: 10.1093/bioinformatics/btp710. Epub 2009 Dec 29.
Abstract
GWAF, Genome-Wide Association analyses with Family, is an R package designed for GWAF. It implements association tests between a batch of genotyped or imputed single nucleotide polymorphisms (SNPs) and a binary or continuous trait with user specified genetic model, and generates informative results from the analyses. In addition, GWAF provides functions to visualize results. We evaluated GWAF using a simulated continuous trait and a binary trait dichotomized from the simulated continuous trait with real genotype data from the Framingham Heart Study's SNP Health Association Resource project.
摘要
GWAF，即带有家族信息的全基因组关联分析，是一款专为全基因组关联分析而设计的 R 包。它实现了用户指定遗传模型下一批基因分型或 imputed 的单核苷酸多态性 (SNP) 与二分类或连续性状之间的关联分析，并从分析中生成有用的结果。此外，GWAF 还提供了可视化结果的功能。我们使用模拟的连续性状和从模拟的连续性状中二分得到的二分类性状，以及 Framingham Heart Study 的 SNP Health Association Resource 项目中的真实基因型数据，对 GWAF 进行了评估。
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