曲马多在小鼠体内抗抑郁活性的评价。
Evaluation of antidepressant activity of tramadol in mice.
机构信息
Department of Pharmacology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, New Delhi 110 002, India.
出版信息
Indian J Pharmacol. 2008 Jun;40(3):129-30. doi: 10.4103/0253-7613.42307.
Abstract
OBJECTIVE
To evaluate antidepressant like effect of tramadol in mice.
MATERIALS AND METHODS
Tramadol was administered at three different doses (10,20 and 40 mg/kg, i.p) once daily for 7 days to Swiss albino mice of either sex. The immobility period of control and drug treated mice were recorded in tail suspension test (TST).The antidepressant effect of tramadol was compared to that of fluoxetine (20 mg/kg, i.p), administered for seven days.
RESULTS
Tramadol produced significant antidepressant effect at all the doses, as indicated by reduction in immobility times as compared to control. The efficacy of tramadol at doses of 20 and 40 mg/kg was comparable with that of fluoxetine. Tramadol at 10 mg/kg dose showed significantly less antidepressant activity compared to fluoxetine.
CONCLUSION
The results of the present study indicate antidepressant like activity of tramadol.
摘要
目的
评估曲马多在小鼠体内的抗抑郁样作用。
材料与方法
将曲马多以三种不同剂量（10、20 和 40 mg/kg，ip）每天一次连续给药 7 天，用于雄性和雌性瑞士白化小鼠。在悬尾试验（TST）中记录对照组和药物处理组小鼠的不动期。将曲马多的抗抑郁作用与氟西汀（20 mg/kg，ip）进行比较，氟西汀给药 7 天。
结果
与对照组相比，曲马多在所有剂量下均产生显著的抗抑郁作用，表现为不动时间减少。曲马多在 20 和 40 mg/kg 剂量下的疗效与氟西汀相当。曲马多在 10 mg/kg 剂量下的抗抑郁活性明显低于氟西汀。
结论
本研究结果表明曲马多具有抗抑郁样活性。
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