Younus Ishrat, Siddiq And Afshan
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan.
Faculty of Pharmacy, Hamdard University, Karachi, Pakistan.
Afr J Tradit Complement Altern Med. 2017 Mar 1;14(3):142-146. doi: 10.21010/ajtcam.v14i3.15. eCollection 2017.
Currently-available antidepressant agents produce various adverse effects, and are expensive. At present, various plants are being evaluated for their possible role against numerous diseases, and no doubt, the role of traditional and complementary medicines in the development of effective therapy is incredible. The present study was designed to evaluate antidepressant-like activity of L. Var. at different doses in mice.
Antidepressant potential of ethanolic extract of L. was evaluated at three different doses 250 mg/kg, 500 mg/kg and 1000 mg/kg by using forced swim test and tail suspension test on albino male mice. The results were compared with control and standard mice groups administered with normal saline and Fluoxetine respectively. In both parameters immobility period was recorded two times during 60 days dosing.
The ethanol extract at all three tested doses (250 mg/kg, 500 mg/kg and 1000 mg/kg) and standard fluoxetine demonstrated notable antidepressant-like activity (p<0.05) in both FST and TST paradigms.
Our results clearly show that ameliorate depression-like behavior in rodent model, and can be used to establish newer antidepressant approaches in future. However, mechanism-based studies are needed to establish the mechanistic action of L. EERC Ethanol Extract of FST Forced swim test: TSTTail suspension test.
目前可用的抗抑郁药会产生各种不良反应，且价格昂贵。目前，各种植物正在接受评估，以确定它们对多种疾病可能发挥的作用，毫无疑问，传统和补充药物在有效治疗方法的开发中所起的作用是不可估量的。本研究旨在评估不同剂量的L. Var. 在小鼠中的抗抑郁样活性。
通过对白化雄性小鼠进行强迫游泳试验和悬尾试验，以250 mg/kg、500 mg/kg和1000 mg/kg这三种不同剂量评估L. 的乙醇提取物的抗抑郁潜力。将结果分别与给予生理盐水的对照组和给予氟西汀的标准小鼠组进行比较。在60天给药期间，在两个参数中均记录了不动时间。
在强迫游泳试验和悬尾试验范式中，所有三个测试剂量（250 mg/kg、500 mg/kg和1000 mg/kg）的乙醇提取物以及标准氟西汀均表现出显著的抗抑郁样活性（p<0.05）。
我们的结果清楚地表明，L. 可改善啮齿动物模型中的抑郁样行为，并可用于未来建立新的抗抑郁方法。然而，需要进行基于机制的研究来确定L. 的作用机制。EERC乙醇提取物；FST强迫游泳试验；TST悬尾试验
