Department of Pediatrics, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India.
Indian J Pharmacol. 2008 Aug;40(4):186-7. doi: 10.4103/0253-7613.43168.
Ondansetron is a serotonin receptor antagonist used widely in the prophylaxis and treatment of postoperative nausea and vomiting (PONV) and vomiting associated with cancer chemotherapy. The common side effects of ondansetron are fever, malaise, diarrhoea, constipation, and allergic reactions. Extra-pyramidal reactions are rare and cardiovascular side effects are even rarer. Even though its clinical safety has been established in a large number of studies, its adverse effects have been reported and these include cardiovascular events like acute myocardial ischemia and arrhythmias in adults.([1]) Studies of its adverse effects in children are few. We report a rare adverse effect of ondansetron in a 14-year-old girl, presenting as ventricular tachycardia.
昂丹司琼是一种广泛用于预防和治疗术后恶心和呕吐（PONV）以及与癌症化疗相关的呕吐的 5-羟色胺受体拮抗剂。昂丹司琼的常见副作用有发热、不适、腹泻、便秘和过敏反应。锥体外系反应罕见，心血管副作用更罕见。尽管其在大量研究中已确立了临床安全性，但也有报道称其存在不良反应，包括成人的心血管事件，如急性心肌缺血和心律失常。([1]) 关于其在儿童中的不良反应研究较少。我们报告了一例 14 岁女孩使用昂丹司琼后出现罕见的不良反应，表现为室性心动过速。
