Hospital General Universitario Gregorio Marañón de Madrid, Spain.
Eur J Clin Pharmacol. 2010 Apr;66(4):323-30. doi: 10.1007/s00228-009-0774-9. Epub 2009 Dec 30.
The proton pump inhibitors are first-line drugs for the treatment of a number of gastrointestinal diseases. These drugs have a good safety profile, making it possible to use them in paediatric patients. Although their pharmacokinetics in children has not been extensively studied, research performed suggests that the dose used should be varied as a function of age, as this factor affects the drug's metabolism. Proton pump inhibitors can be used in critically ill children for the prophylaxis and treatment of gastrointestinal haemorrhage, although there is still little experience with this. The most widely used proton pump inhibitor at the present time is omeprazole. As there are specific characteristics of these patients that could alter the pharmacokinetics of the drugs, studies need to be performed to determine the most suitable dose and dosage interval.
质子泵抑制剂是治疗多种胃肠道疾病的一线药物。这些药物具有良好的安全性，使得它们可以在儿科患者中使用。尽管它们在儿童中的药代动力学尚未得到广泛研究，但已进行的研究表明，应根据年龄调整剂量，因为这一因素会影响药物的代谢。质子泵抑制剂可用于重症患儿预防和治疗胃肠道出血，但经验仍较少。目前使用最广泛的质子泵抑制剂是奥美拉唑。由于这些患者存在可能改变药物药代动力学的特定特征，因此需要进行研究以确定最合适的剂量和给药间隔。
