Laboratory of Nuclear Medicine of the Department of Endocrinology and Diabetology, Nicolaus Copernicus University, Torun, Collegium Medicum, Bydgoszcz, Bydgoszcz, Poland.
Endokrynol Pol. 2009 Nov-Dec;60(6):437-42.
The aim of the study was to estimate the influence of nicotine on thyroid volume according to patients' sex.
A group of 160 patients with thyroid disorders in their past medical history was examined. Patients were divided into two groups: Group A contained 50 patients with goiter, where the volume of the thyroid was evaluated with use of US and (131)I-SPECT; group B contained 50 patients with goiter, where the volume of the thyroid was evaluated with use of US and (99m)Tc-SPECT. There were two control groups: Group A' contained 30 patients with normal volume of the thyroid gland shown by US and (131)I-SPECT, and group B' contained 30 patients with normal volume of the thyroid gland shown by US and (99m)Tc-SPECT. The patients from the examined and control groups were divided into two subgroups - smokers and non-smokers. US of the thyroid gland was made by means of an ALOKA SSD 500 device. SPECT was performed by means of a singke-headed gamma camera by Diacam.
The average volume of thyroid gland measured by (131)I-SPECT and (99m)Tc-SPECT was significantly larger according to US in the examined and control groups in smokers and non-smokers. We did not show statistically significant correlations between levels of iodine uptake and volumes of goiter evaluated by US examination together with (131)I scintigraphy.
Significant differences in average values of thyroid volume between smokers and non-smokers were not observed, which might suggest a lack of goitrogenic activity of tobacco smoke or indicates a potential goitrogenic influence not significant enough in the examined group.
本研究旨在根据患者性别评估尼古丁对甲状腺体积的影响。
对 160 名有甲状腺疾病病史的患者进行了检查。患者分为两组：A 组包含 50 名甲状腺肿患者，使用 US 和 (131)I-SPECT 评估甲状腺体积；B 组包含 50 名甲状腺肿患者，使用 US 和 (99m)Tc-SPECT 评估甲状腺体积。有两个对照组：A'组包含 30 名 US 和 (131)I-SPECT 显示甲状腺正常体积的患者，B'组包含 30 名 US 和 (99m)Tc-SPECT 显示甲状腺正常体积的患者。检查和对照组的患者分为两组——吸烟者和非吸烟者。甲状腺 US 使用 ALOKA SSD 500 设备进行。SPECT 使用 Diacam 单探头伽马相机进行。
在吸烟者和非吸烟者中，根据 US 检查，经 (131)I-SPECT 和 (99m)Tc-SPECT 测量的甲状腺平均体积在检查组和对照组中均显著增大。我们没有显示出碘摄取水平与 US 检查评估的甲状腺肿体积之间存在统计学显著相关性。
在吸烟者和非吸烟者之间，甲状腺体积的平均值没有观察到显著差异，这可能表明烟草烟雾缺乏致甲状腺肿活性，或者表明在检查组中潜在的致甲状腺肿影响不够显著。
