Irvine2 Vascular Labs & Microcirculation, Physiology, Department of Biomedical Sciences, G D'Annunzio University, General Surgery, Guardiagrele (Ch)-Ortona (Pe) Pescara, San Valentino Vascular Screening Project, Italy.
Phytother Res. 2010 Mar;24(3):438-44. doi: 10.1002/ptr.3021.
We investigated the efficacy of orally and topically applied Pycnogenol for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days' treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol-treated groups than in the control group given placebo (p < 0.05), showing the efficacy of Pycnogenol for relieving signs and symptoms of acute external hemorrhoids. In a group of patients given topical (0.5%) Pycnogenol in addition to oral Pycnogenol the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol eases the management of acute hemorrhoidal attacks and help avoid bleedings.
我们在一项有 84 名受试者参与的对照、随机研究中，调查了口服和局部应用碧萝芷®治疗急性痔发作的疗效。在急性发作开始后不到 48 小时内，我们招募了患者并对体征和症状进行评分。在治疗 7 天后和停止治疗后 7 天再次进行评估。与接受安慰剂的对照组相比，碧萝芷®治疗组的评分下降明显更显著（p < 0.05），表明碧萝芷®在缓解急性外痔的体征和症状方面具有疗效。在一组除了口服碧萝芷®之外还局部应用（0.5%）碧萝芷®的患者中，症状的改善开始更快且更明显。在接受碧萝芷®治疗 7 天的所有患者中，最突出的症状，痔出血完全消失，在 14 天的随访中也是如此。相比之下，在对照组中，在两周的随访中仍观察到出血。这项研究表明，口服和局部应用的碧萝芷®均能有效控制这种常见的、使人丧失能力的健康问题。应用碧萝芷®可简化急性痔发作的管理，并有助于避免出血。
