Department of Radiation Biology, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Phytother Res. 2010 Jun;24 Suppl 2:S204-8. doi: 10.1002/ptr.3091.
The small intestine displays numerous morphological and functional alterations after exposure to ionizing radiations. Oxidative stress and changes in monoamines levels may contribute toward some of these alterations. The objective of the current work is to evaluate the efficacy of lycopene on radiation-induced damage in the small intestine. Lycopene (5 mg/kg BW) was given to male albino rats, via gavages for 7 days before whole body exposure to gamma ray (6 Gy). Irradiated animals, sacrificed 7 days after irradiation, showed sloughing villi, ulcers, and ruptured goblet cells, shrinkage of submucosa layers, more fibers and fibroblasts. Histopathological changes were associated with a significant increase in thiobarbituric acid reactive substances (TBARS) and alteration in xanthine oxidoreductase system (XOR). In parallel, significant decreases in reduced glutathione (GSH) content, superoxide dismutase (SOD) and catalase (CAT) activities were recorded. Gamma irradiation has also induced a significant decrease in the level of monoamines: serotonin (5-HT), dopamine (DA), norepinephrine (NE), and epinephrine (EPI) associated with an increase in monoamine-oxidase (MAO) activity. Lycopene pretreatment has significantly improved the oxidant/antioxidant status, which was associated with significant regeneration of the small intestine, and improved monoamines levels. Based on these results, it is concluded that lycopene may protect the small intestine against radiation-induced damage.
小肠在暴露于电离辐射后会发生许多形态和功能上的改变。氧化应激和单胺水平的变化可能是导致这些改变的原因之一。本研究的目的是评估番茄红素对小肠辐射损伤的疗效。番茄红素（5mg/kgBW）通过灌胃给予雄性白化大鼠，连续 7 天，然后对其进行全身γ射线（6Gy）照射。照射后 7 天处死的动物显示绒毛脱落、溃疡和杯状细胞破裂、黏膜下层收缩、纤维和成纤维细胞增多。组织病理学变化与丙二醛（TBARS）反应性物质和黄嘌呤氧化还原酶系统（XOR）的显著改变相关。同时，还原型谷胱甘肽（GSH）含量、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性显著降低。γ 射线照射还导致单胺类物质：5-羟色胺（5-HT）、多巴胺（DA）、去甲肾上腺素（NE）和肾上腺素（EPI）水平显著降低，与单胺氧化酶（MAO）活性增加相关。番茄红素预处理显著改善了氧化应激/抗氧化状态，这与小肠的显著再生和单胺类物质水平的改善有关。基于这些结果，可以得出结论，番茄红素可能对小肠辐射损伤具有保护作用。
