Motallebnejad Mina, Zahedpasha Shaghayegh, Moghadamnia Ali Akbar, Kazemi Sohrab, Moslemi Daryoush, Pouramir Mahdi, Asgharpour Fariba
Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Caspian J Intern Med. 2020 Fall;11(4):419-425. doi: 10.22088/cjim.11.4.419.
Nowadays, radiotherapy is used effectively for the treatment of head and neck cancers. Mucositis is one of the most important side effects of radiotherapy. Radio-protective agents protect tissues and cells against the adverse effects due to ionizing radiation and cleave radiation-induced free radicals. Lycopene as a potent antioxidant protects cells against oxidative damage by free radical-scavenging. The present study investigated the antioxidant effect of lycopene on oral mucosa of irradiated rats.
In this experimental animal study, 28 rats were placed in four groups as follows: treated with 50 mg /kg of lycopene (L50), solvent+irradiation (SR), 25 mg / kg of lycopene+irradiation (LR25), and 50 mg / kg of lycopene+irradiation (LR50). The rats received lycopene intraperitoneally. On the irradiation day (day 0) and tenth day of radiation, blood samples were taken from the animals for FRAP and TBARS tests.
The results showed that the LR50 group did not show mucositis higher than grade 2. There was a significant difference (p<0.05) between SR and the L50 regarding the severity of mucositis. In addition, L50 showed higher antioxidant activity and lower peroxidation than SR.
Lycopene reduced the severity of mucositis. Therefore, it can be used as a potential and promising nutritional substance to prevent radiotherapy complications, especially in the treatment of head and neck cancers. However, further research is necessary to confirm these results.
如今，放射疗法被有效地用于治疗头颈癌。黏膜炎是放射疗法最重要的副作用之一。辐射防护剂可保护组织和细胞免受电离辐射的不利影响，并裂解辐射诱导的自由基。番茄红素作为一种有效的抗氧化剂，通过清除自由基来保护细胞免受氧化损伤。本研究调查了番茄红素对受辐照大鼠口腔黏膜的抗氧化作用。
在这项实验动物研究中，28只大鼠被分为四组，如下所示：用50mg/kg番茄红素处理（L50）、溶剂+辐照（SR）、25mg/kg番茄红素+辐照（LR25）和50mg/kg番茄红素+辐照（LR50）。大鼠通过腹腔注射接受番茄红素。在辐照当天（第0天）和辐射的第10天，从动物身上采集血样进行FRAP和TBARS测试。
结果表明，LR50组的黏膜炎未高于2级。SR组和L50组在黏膜炎严重程度方面存在显著差异（p<0.05）。此外，L50组比SR组表现出更高的抗氧化活性和更低的过氧化水平。
番茄红素降低了黏膜炎的严重程度。因此，它可作为一种潜在且有前景的营养物质用于预防放疗并发症，尤其是在头颈癌的治疗中。然而，需要进一步的研究来证实这些结果。
