Universitätsklinikum München, Institut für Klinische Chemie, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377 München.
Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1026-51. doi: 10.1002/anie.200903363.
Clinical chemistry and laboratory medicine can look back over more than 150 years of eventful history. The subject encompasses all the medicinal disciplines as well as the remaining natural sciences. Clinical chemistry demonstrates how new insights from basic research in biochemical, biological, analytical chemical, engineering, and information technology can be transferred into the daily routine of medicine to improve diagnosis, therapeutic monitoring, and prevention. This Review begins with a presentation of the development of clinical chemistry. Individual steps between the drawing of blood and interpretation of laboratory data are then illustrated; here not only are pitfalls described, but so are quality control systems. The introduction of new methods and trends into medicinal analysis is explored, along with opportunities and problems associated with personalized medicine.
临床化学和实验医学可以追溯到 150 多年来的丰富历史。该学科涵盖了所有医学学科以及其余的自然科学。临床化学展示了基础研究中生物化学、生物学、分析化学、工程和信息技术方面的新见解如何能够被转移到医学的日常实践中，以改善诊断、治疗监测和预防。这篇综述首先介绍了临床化学的发展。然后，展示了从采血到解释实验室数据的各个步骤；这里不仅描述了陷阱，还描述了质量控制系统。探索了新方法和趋势在医学分析中的引入，以及与个体化医学相关的机遇和问题。
