Research Institute of Health Sciences, Korea University, Seoul, Republic of Korea.
J Med Food. 2009 Dec;12(6):1281-5. doi: 10.1089/jmf.2009.0098.
In the present study, the anti-stress effects of yeast hydrolysate (YH) were investigated. The YH consisted of crude carbohydrate (23.6%) and crude protein (68.3%) with low contents of crude ash (3.1%) and crude fat (0.3%). Also, acidic amino acids (glutamic acid + aspartic acid) were present in large quantities (14.2 and 5.0 mol%, respectively). Pronase digestion had little effect on the affinity of the YH on 5-hydroxytryptamine (serotonin) and norepinephrine transporters, whereas NaIO(4) oxidation of the hydrolysate decreased the affinity by about 10% at 1,000 microg/mL, indicating that the periodate-labile carbohydrate moiety played a leading role in the affinity effects of the carbohydrate in YH. As a result of brain mapping after the administration of the YH for 3 days in human subjects, a symmetrical distribution of theta and alpha waves in the central and parietal lobes was observed. This brain mapping pattern of theta and alpha wave distribution appears in a psychologically stable state. The YH groups showed improvements in Beck Depression Inventory and Beck Anxiety Inventory scores after YH administration for 2 weeks. Treatment also seemed to have a more significant (P < .05) impact on the somatic manifestations of anxiety as indexed by the Beck Anxiety Inventory scores. Food materials used as a source of YH have been found to be associated with increases in alertness and adaptation to stress.
在本研究中，研究了酵母水解物（YH）的抗应激作用。YH 由粗碳水化合物（23.6%）和粗蛋白（68.3%）组成，粗灰分（3.1%）和粗脂肪（0.3%）含量低。此外，酸性氨基酸（谷氨酸+天冬氨酸）含量丰富（分别为 14.2 和 5.0 摩尔%）。蛋白酶消化对 YH 与 5-羟色胺（血清素）和去甲肾上腺素转运体的亲和力几乎没有影响，而水解物的 NaIO（4）氧化在 1000μg/mL 时使亲和力降低约 10%，表明糖部分的过碘酸盐不稳定碳水化合物在 YH 碳水化合物亲和力效应中起主导作用。在给予 YH 3 天后对人体进行脑部映射的结果表明，中央和顶叶的θ波和α波呈对称分布。这种θ波和α波分布的脑图模式出现在心理稳定状态。在给予 YH 2 周后，YH 组的贝克抑郁量表和贝克焦虑量表评分均有所改善。治疗似乎对贝克焦虑量表评分所指示的焦虑的躯体表现也有更显著的（P <.05）影响。作为 YH 来源的食物材料已被发现与警觉性提高和应激适应有关。
