Department of Microbiology and Immunology, Biosciences Institute, São Paulo State University, Botucatu, São Paulo 18618-000, Brazil.
Parasite Immunol. 2010 Jan;32(1):74-8. doi: 10.1111/j.1365-3024.2009.01160.x.
In this study, we investigated the characteristics of the infection and subsequent immunity induced by Strongyloides venezuelensis in Lewis rats. Animals were infected with 4000 L3 of S. venezuelensis and number of eggs per gram of faeces indicated an acute phase around day 8 and a recovery phase around day 32 after infection. A strong Th2 polarization during recovery phase was ascertained by a significant increase in IgG1 and IgE compared with that in the acute period. A shift in the cytokine profile confirmed these findings. A predominant production of IFN-gamma during the acute phase was followed by IL-10 production during recovery. Together these findings show that experimental infection of Lewis rats with S. venezuelensis presents a kinetics of parasite establishment and immunity similar to that described in other models of helminthic infection.
在这项研究中，我们调查了委内瑞拉钩虫感染和随后诱导的免疫特性在刘易斯大鼠。动物感染了 4000 条 S. venezuelensis 的 L3，粪便中的卵数表明在感染后第 8 天出现急性期，第 32 天出现恢复期。与急性期相比，恢复期 IgG1 和 IgE 的显著增加表明存在强烈的 Th2 极化。细胞因子谱的转变证实了这些发现。急性期 IFN-γ的大量产生随后是恢复期 IL-10 的产生。这些发现表明，用 S. venezuelensis 对刘易斯大鼠进行实验感染，其寄生虫建立和免疫的动力学与其他寄生虫感染模型所描述的相似。
