Department of Microbiology and Immunology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.
Immunol Res. 2011 Dec;51(2-3):205-14. doi: 10.1007/s12026-011-8258-2.
Mice have been used to the study the mechanisms of protective innate and adaptive immunity to larval Strongyloides stercoralis. During primary infection, neutrophils and eosinophils are attracted by parasite components and kill the larvae by release of granule products. Eosinophils also function as antigen-presenting cells for the induction of a Th2 response. B cells produce both IgM and IgG that collaborate with neutrophils to kill worms in the adaptive immune response. Vaccine studies have identified a recombinant diagnostic antigen that induced high levels of immunity to infection with S. stercoralis in mice. These studies demonstrate that there are redundancies in the mechanisms used by the immune response to kill the parasite and that a vaccine with a single antigen may be suitable as a prophylactic vaccine to prevent human strongyloidiasis.
已经使用小鼠来研究幼虫性粪类圆线虫保护性先天和适应性免疫的机制。在初次感染中，中性粒细胞和嗜酸性粒细胞被寄生虫成分吸引，并通过释放颗粒产物杀死幼虫。嗜酸性粒细胞也作为抗原呈递细胞，诱导 Th2 反应。B 细胞产生 IgM 和 IgG，与中性粒细胞协同作用，在适应性免疫反应中杀死蠕虫。疫苗研究已经确定了一种重组诊断抗原，该抗原在诱导对 S. stercoralis 感染的高免疫水平方面非常有效。这些研究表明，免疫反应杀死寄生虫的机制存在冗余性，并且含有单一抗原的疫苗可能适合作为预防人类粪类圆线虫病的预防性疫苗。
