Nanomaterials Optoelectronics Laboratory, Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA.
Biosens Bioelectron. 2010 Mar 15;25(7):1553-65. doi: 10.1016/j.bios.2009.12.001. Epub 2009 Dec 11.
The development of implantable biosensors for continuous monitoring of metabolites is an area of sustained scientific and technological interests. On the other hand, nanotechnology, a discipline which deals with the properties of materials at the nanoscale, is developing as a potent tool to enhance the performance of these biosensors. This article reviews the current state of implantable biosensors, highlighting the synergy between nanotechnology and sensor performance. Emphasis is placed on the electrochemical method of detection in light of its widespread usage and substantial nanotechnology based improvements in various aspects of electrochemical biosensor performance. Finally, issues regarding toxicity and biocompatibility of nanomaterials, along with future prospects for the application of nanotechnology in implantable biosensors, are discussed.
可植入生物传感器用于连续监测代谢物的开发是一个持续的科学和技术兴趣领域。另一方面，纳米技术是一门研究纳米尺度下材料性质的学科，它正在发展成为增强这些生物传感器性能的有力工具。本文综述了可植入生物传感器的现状，强调了纳米技术与传感器性能之间的协同作用。鉴于电化学检测方法在电化学生物传感器性能的各个方面的广泛应用和实质性的纳米技术改进，本文重点介绍了电化学检测方法。最后，讨论了纳米材料的毒性和生物相容性问题，以及纳米技术在可植入生物传感器中的应用前景。
