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In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms.CEM-101 对具有明确大环内酯类耐药机制的肺炎链球菌和化脓性链球菌的体外活性。
Antimicrob Agents Chemother. 2010 Jan;54(1):230-8. doi: 10.1128/AAC.01123-09. Epub 2009 Nov 2.
2
Comparative in vitro susceptibilities of human mycoplasmas and ureaplasmas to a new investigational ketolide, CEM-101.人型支原体和脲原体对新型研究性酮内酯类药物CEM-101的体外敏感性比较
Antimicrob Agents Chemother. 2009 May;53(5):2139-41. doi: 10.1128/AAC.00090-09. Epub 2009 Mar 2.
3
In vitro activity of the investigational ketolide cethromycin against macrolide- and penicillin-resistant Streptococcus pneumoniae: review of the 1998 to 2006 Canadian Respiratory Organism Susceptibility Study (CROSS).研究性酮内酯类药物塞红霉素对大环内酯类和青霉素耐药肺炎链球菌的体外活性：1998年至2006年加拿大呼吸道病原体敏感性研究（CROSS）综述
J Antimicrob Chemother. 2009 Mar;63(3):620-2. doi: 10.1093/jac/dkn532. Epub 2009 Jan 16.

CEM-101，一种新型氟酮内酯的 MIC 质量控制指南和药敏纸片扩散试验优化

MIC quality control guidelines and disk diffusion test optimization for CEM-101, a novel fluoroketolide.

机构信息

JMI Laboratories, North Liberty, Iowa 52317, USA.

出版信息

J Clin Microbiol. 2010 Apr;48(4):1470-3. doi: 10.1128/JCM.01992-09. Epub 2009 Dec 30.

DOI:10.1128/JCM.01992-09
PMID:20042620
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2849615/
Abstract

The development of diagnostic susceptibility tests for CEM-101, a new fluoroketolide, was addressed by structured studies to determine the optimal disk diffusion test concentration and effects of various testing conditions or supplements and to establish the quality control (QC) ranges for reference broth microdilution tests. The 15-microg CEM-101 disk was selected, and MIC ranges for a total of four QC organisms were proposed, with only three doubling dilutions each that included 95.6 to 99.7% of values reported from the eight-laboratory investigation.

摘要

通过结构化研究解决了新型氟酮内酯 CEM-101 的诊断药敏试验的开发问题，以确定最佳的纸片扩散试验浓度以及各种测试条件或添加物的影响，并为参考肉汤微量稀释试验建立质量控制（QC）范围。选择了 15μg 的 CEM-101 药敏纸片，提出了总共四个 QC 菌的 MIC 范围，每个范围仅包括三个二倍稀释度，其中包括来自八个实验室研究的 95.6%至 99.7%的报告值。