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新型氟代酮内酯类抗菌药物索利霉素对淋病奈瑟菌的纸片扩散法及最低抑菌浓度质量控制指南的测定

Determination of Disk Diffusion and MIC Quality Control Guidelines for Solithromycin, a Novel Fluoroketolide Antibacterial, against Neisseria gonorrhoeae.

作者信息

Riedel Stefan, Ross James E, Farrell David J, Flamm Robert K, Jones Ronald N

机构信息

The Johns Hopkins University, Baltimore, Maryland, USA

JMI Laboratories, North Liberty, Iowa, USA.

出版信息

J Clin Microbiol. 2015 Dec;53(12):3888-90. doi: 10.1128/JCM.02250-15. Epub 2015 Sep 16.

DOI:10.1128/JCM.02250-15
PMID:26378286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4652126/
Abstract

This solithromycin quality control study was performed to establish quality control (QC) ranges for the N. gonorrhoeae ATCC 49226 control strain for MIC agar dilution testing (AD) and zones by disk diffusion testing (DD). The following ranges were established: AD, 0.03 to 0.25 μg/ml, and DD, 33 to 43 mm. In January 2015, the CLSI Subcommittee on Antimicrobial Susceptibility Testing approved these ranges, which will be important when evaluating solithromycin against clinical isolates of N. gonorrhoeae.

摘要

进行这项索利霉素质量控制研究是为了确定淋病奈瑟菌ATCC 49226对照菌株在MIC琼脂稀释试验（AD）和纸片扩散试验（DD）中的质量控制（QC）范围。确定的范围如下：AD为0.03至0.25μg/ml，DD为33至43mm。2015年1月，CLSI抗菌药物敏感性试验小组委员会批准了这些范围，这在评估索利霉素对淋病奈瑟菌临床分离株时将很重要。

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本文引用的文献

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A Phase 2 Trial of Oral Solithromycin 1200 mg or 1000 mg as Single-Dose Oral Therapy for Uncomplicated Gonorrhea.口服索利霉素 1200mg 或 1000mg 单次口服治疗单纯性淋病的 2 期临床试验。
Clin Infect Dis. 2015 Oct 1;61(7):1043-8. doi: 10.1093/cid/civ478. Epub 2015 Jun 18.
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Global resistance of Neisseria gonorrhoeae: when theory becomes reality.淋病奈瑟菌的全球耐药性：理论变为现实。
Curr Opin Infect Dis. 2014 Feb;27(1):62-7. doi: 10.1097/QCO.0000000000000025.
3
In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?新型氟喹诺酮酮内酯司帕沙星（CEM-101）对大量临床淋病奈瑟菌分离株和国际参考菌株的体外活性，包括那些具有高水平抗菌耐药性的菌株：淋病的潜在治疗选择？
Antimicrob Agents Chemother. 2012 May;56(5):2739-42. doi: 10.1128/AAC.00036-12. Epub 2012 Feb 21.
4
The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009).在体外评估索利霉素（CEM-101）对 2009 年在美国和欧洲分离的病原体的作用。
J Infect. 2010 Dec;61(6):476-83. doi: 10.1016/j.jinf.2010.08.010. Epub 2010 Sep 8.
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CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria.CEM-101，一种新型氟酮内酯：对多种革兰氏阳性菌和革兰氏阴性菌的抗菌活性。
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