Roush James K, Cross Alan R, Renberg Walter C, Dodd Chadwick E, Sixby Kristin A, Fritsch Dale A, Allen Timothy A, Jewell Dennis E, Richardson Daniel C, Leventhal Phillip S, Hahn Kevin A
Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA.
J Am Vet Med Assoc. 2010 Jan 1;236(1):67-73. doi: 10.2460/javma.236.1.67.
To evaluate the effects of a food supplemented with fish oil omega-3 fatty acids on weight bearing in dogs with osteoarthritis.
Randomized, double-blinded, controlled clinical trial.
38 client-owned dogs with osteoarthritis examined at 2 university veterinary clinics.
Dogs were randomly assigned to receive a typical commercial food (n = 16) or a test food (22) containing 3.5% fish oil omega-3 fatty acids. On day 0 (before the trial began) and days 45 and 90 after the trial began, investigators conducted orthopedic evaluations and force-plate analyses of the most severely affected limb of each dog, and owners completed questionnaires to characterize their dogs' arthritis signs.
The change in mean peak vertical force between days 90 and 0 was significant for the test-food group (5.6%) but not for the control-food group (0.4%). Improvement in peak vertical force values was evident in 82% of the dogs in the test-food group, compared with 38% of the dogs in the control-food group. In addition, according to investigators' subjective evaluations, dogs fed the test food had significant improvements in lameness and weight bearing on day 90, compared with measurements obtained on day 0.
At least in the short term, dietary supplementation with fish oil omega-3 fatty acids resulted in an improvement in weight bearing in dogs with osteoarthritis.
评估添加鱼油ω-3脂肪酸的食物对骨关节炎犬负重的影响。
随机、双盲、对照临床试验。
在2所大学兽医诊所检查的38只患骨关节炎的客户拥有犬。
犬被随机分配接受典型商业食物（n = 16）或含3.5%鱼油ω-3脂肪酸的试验食物（22只）。在第0天（试验开始前）以及试验开始后的第45天和第90天，研究者对每只犬受影响最严重的肢体进行骨科评估和测力板分析，并且主人完成问卷以描述其犬的关节炎症状。
试验食物组在第90天和第0天之间平均垂直峰值力的变化显著（5.6%），而对照食物组不显著（0.4%）。试验食物组中82%的犬垂直峰值力值有改善，相比之下，对照食物组中这一比例为38%。此外，根据研究者的主观评估，与第0天的测量结果相比，喂食试验食物的犬在第90天时跛行和负重情况有显著改善。
至少在短期内，饮食中补充鱼油ω-3脂肪酸可改善骨关节炎犬的负重情况。
