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给犬类喂食鱼油和中链甘油三酯会影响循环中的结构脂质和能量脂质、内源性大麻素以及非脂质代谢物谱。

Feeding of fish oil and medium-chain triglycerides to canines impacts circulating structural and energetic lipids, endocannabinoids, and non-lipid metabolite profiles.

作者信息

Jackson Matthew I, Jewell Dennis E

机构信息

Pet Nutrition Center, Hill's Pet Nutrition, Inc., Topeka, KS, United States.

Department of Grain Science and Industry, Kansas State University, Manhattan, KS, United States.

出版信息

Front Vet Sci. 2023 Aug 24;10:1168703. doi: 10.3389/fvets.2023.1168703. eCollection 2023.

DOI:10.3389/fvets.2023.1168703
PMID:37691632
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10484482/
Abstract

INTRODUCTION

The effect of medium-chain fatty acid-containing triglycerides (MCT), long-chain polyunsaturated fatty acid-containing triglycerides from fish oil (FO), and their combination (FO+MCT) on the serum metabolome of dogs () was evaluated.

METHODS

Dogs ( = 64) were randomized to either a control food, one with 7% MCT, one with FO (0.18% eicosapentaenoate and 1.3% docosahexaenoate), or one with FO+MCT for 28 days following a 14-day washout period on the control food. Serum metabolites were analyzed via chromatography followed by mass spectrometry.

RESULTS

Additive effects of serum metabolites were observed for a number of metabolite classes, including fatty acids, phospholipids, acylated amines including endocannabinoids, alpha-oxidized fatty acids, and methyl donors. Some effects of the addition of FO+MCT were different when the oils were combined compared with when each oil was fed separately, namely for acylcarnitines, omega-oxidized dicarboxylic acids, and amino acids. Several potentially beneficial effects on health were observed, including decreased circulating triglycerides and total cholesterol with the addition of FO (with or without MCT) and decreases in N-acyl taurines with the addition of MCT, FO, or FO+MCT.

DISCUSSION

Overall, the results of this study provide a phenotypic characterization of the serum lipidomic response to dietary supplementation of long-chain n3-polyunsaturated and medium-chain saturated fats in canines.

摘要

引言

评估了含中链脂肪酸甘油三酯（MCT）、鱼油中含长链多不饱和脂肪酸甘油三酯（FO）及其组合（FO+MCT）对犬血清代谢组的影响。

方法

64只犬在对照食物上经过14天的洗脱期后，随机分为接受对照食物、含7% MCT的食物、含FO（0.18%二十碳五烯酸和1.3%二十二碳六烯酸）的食物或含FO+MCT的食物，为期28天。通过色谱法随后进行质谱分析血清代谢物。

结果

在许多代谢物类别中观察到血清代谢物的加性效应，包括脂肪酸、磷脂、包括内源性大麻素在内的酰化胺、α-氧化脂肪酸和甲基供体。与分别喂食每种油时相比，当将油混合时，添加FO+MCT的一些效应有所不同，即对于酰基肉碱、ω-氧化二羧酸和氨基酸。观察到了一些对健康的潜在有益影响，包括添加FO（有或没有MCT）时循环甘油三酯和总胆固醇降低，以及添加MCT、FO或FO+MCT时N-酰基牛磺酸降低。

讨论

总体而言，本研究结果提供了犬血清脂质组对膳食补充长链n3-多不饱和脂肪酸和中链饱和脂肪反应的表型特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/ff8840c7e0cd/fvets-10-1168703-g0009.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/ad6b8f19939a/fvets-10-1168703-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/78aaf587f8c9/fvets-10-1168703-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/111797d63743/fvets-10-1168703-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/ea4e56baf2d5/fvets-10-1168703-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5182/10484482/ff8840c7e0cd/fvets-10-1168703-g0009.jpg

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