通过对犬猫干血斑中二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的分析推导ω-3指数
Derivation of the Omega-3 Index from EPA and DHA Analysis of Dried Blood Spots from Dogs and Cats.
作者信息
Harris William S, Jackson Kristina H, Carlson Heather, Hoem Nils, Dominguez Tonje E, Burri Lena
机构信息
Fatty Acid Research Institute, Sioux Falls, SD 57106, USA.
Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA.
出版信息
Vet Sci. 2022 Dec 26;10(1):13. doi: 10.3390/vetsci10010013.
The Omega-3 Index (O3I) is the red blood cell (RBC) eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) content expressed as a percentage of total RBC fatty acids. Although a validated biomarker of omega-3 status in humans, little is known about the O3I status of dogs and cats; species in which omega-3 fatty acids have known health benefits. The purpose of this study was to develop equations to predict the O3I in these species from a dried blood spot (DBS) analysis. Random blood samples from 33 dogs and 10 cats were obtained from a community veterinary clinic. DBS and RBC samples were analyzed for fatty acid composition. For both species, the R2 between the DBS EPA + DHA value and the O3I was >0.96 (p < 0.001). The O3I was roughly 75% lower in dogs and cats than in humans. We conclude that the O3I can be estimated from a DBS sample, and the convenience of DBS collection should facilitate omega-3 research in these companion animals.
欧米伽-3指数（O3I）是指红细胞（RBC）中二十碳五烯酸（EPA）与二十二碳六烯酸（DHA）的含量占红细胞总脂肪酸的百分比。尽管它是人体中欧米伽-3状态的一种经过验证的生物标志物，但对于已知欧米伽-3脂肪酸具有健康益处的犬猫而言，我们对其O3I状态却知之甚少。本研究的目的是建立通过干血斑（DBS）分析来预测这些物种O3I的方程。从一家社区兽医诊所采集了33只犬和10只猫的随机血液样本。对DBS和RBC样本进行了脂肪酸组成分析。对于这两个物种，DBS中EPA + DHA值与O3I之间的R2均>0.96（p < 0.001）。犬猫的O3I比人类大约低75%。我们得出结论，O3I可以从DBS样本中估算出来，DBS采集的便利性应有助于对这些伴侣动物进行欧米伽-3研究。
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