Pérez-Calvo Juan Ignacio, Morales Rull José Luis, Ruiz Ruiz Francisco José
Servicio de Medicina Interna, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
Med Clin (Barc). 2011 Feb 19;136(4):158-62. doi: 10.1016/j.medcli.2009.11.013. Epub 2009 Dec 30.
Cystatin C (CysC) is an antiprotease useful for measuring kidney function. Beyond such property, it carries significant prognostic information in several fields of cardiovascular diseases. We review data that support CysC as a prognostic factor in cardiovascular diseases among healthy elderly, hypertensive and heart failure patients. In addition, it has been speculated that CysC may be an early marker of ventricular remodelling, primarily involved in its pathogenesis, as a local antiprotease. Its role in physiopathology and clinical issues of cardiovascular pathology is yet to be elucidated.
胱抑素C（CysC）是一种用于评估肾功能的抗蛋白酶。除了这一特性外，它在心血管疾病的多个领域还携带重要的预后信息。我们回顾了支持CysC作为健康老年人、高血压患者和心力衰竭患者心血管疾病预后因素的数据。此外，有人推测CysC可能是心室重塑的早期标志物，作为一种局部抗蛋白酶，主要参与其发病机制。其在心血管病理生理病理和临床问题中的作用尚待阐明。
