雄激素剥夺治疗前列腺癌中神经元凋亡抑制蛋白表达的诱导。
Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer.
机构信息
Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, Canada V5Z 1L3.
出版信息
Cancer Lett. 2010 Jun 28;292(2):176-85. doi: 10.1016/j.canlet.2009.11.023. Epub 2009 Dec 30.
Abstract
A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-kappaB that physically associated to previously uncharacterized kappaB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased (p=0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.
摘要
前列腺癌细胞在去雄激素环境中存活的机制仍难以捉摸。在这里，我们发现神经元凋亡抑制蛋白 (NAIP) 的表达在体内和体外均明显增加，以响应雄激素剥夺治疗 (ADT)。NAIP 表达的增加与 NF-κB 的 DNA 结合活性增加相对应，NF-κB 与 NAIP 基因座中以前未表征的 κB 样位点发生物理关联。重要的是，接受 ADT 的前列腺癌患者的临床样本中 NAIP 的表达显著增加（p=0.04）。NAIP 的表达可能与去势治疗后前列腺癌的存活能力增强有关。
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2
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3
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