Department of Physics, California State University Northridge, 18111 Nordhoff Street, Northridge, California 91330-8268, USA.
Nano Lett. 2010 Feb 10;10(2):420-5. doi: 10.1021/nl9029237.
I propose a technique for reading the base sequence of a single DNA molecule using a graphene nanogap to read the DNA's transverse conductance. Because graphene is a single atom thick, single-base resolution of the conductance is readily obtained. The nonlinear current-voltage characteristic is used to determine the base type independent of nanogap-width variations that cause the current to change by 5 orders of magnitude. The expected sequencing error rate is 0% up to a nanogap width of 1.6 nm.
我提出了一种使用石墨烯纳米间隙读取单个 DNA 分子的碱基序列的技术,通过读取 DNA 的横向电导来实现。由于石墨烯只有一个原子厚,因此很容易获得单碱基分辨率的电导。利用非线性电流-电压特性来确定碱基类型,而不受纳米间隙宽度变化的影响,这些变化会导致电流变化 5 个数量级。在纳米间隙宽度为 1.6nm 时,预计测序错误率为 0%。