Haley Gwendolen E, Berteau-Pavy Frederique, Parkv Byung, Raber Jacob
Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, Oregon 97239, USA.
Curr Aging Sci. 2010 Jul;3(2):127-37. doi: 10.2174/1874609811003020127.
Previously we reported that apolipoprotein E (ApoE) epsilon4 negatively affects performance in the novel-image-novel-location (NINL) object recognition test in healthy non-demented elderly human study participants. In this study, the participants were invited to return for testing sessions 6 and 18 months after the baseline session. Using a longitudinal study design, effects of epsilon4 on NINL test performance were assessed in study "dropouts", participants that did not return for the second and/or third session(s), and "finishers", participants that returned for all sessions. There were effects of epsilon4 on dropout rates and NINL total scores as well as sub-scores in both dropouts and finishers. NINL total score was a predictor of epsilon4 participant dropout. Compared to non-epsilon4 dropouts, epsilon4 dropouts had lower NINL scores. In contrast, epsilon4 finishers had higher NINL scores than non-epsilon4 finishers. Thus, the NINL test could be a valuable tool in detecting pre-clinical signs of age-related cognitive impairments, particularly those associated with epsilon4 risk.
此前我们报道，在健康的非痴呆老年人类研究参与者中，载脂蛋白E（ApoE）ε4对新颖图像 - 新颖位置（NINL）物体识别测试的表现有负面影响。在本研究中，邀请参与者在基线测试后的6个月和18个月返回进行测试。采用纵向研究设计，在研究“退出者”（未返回参加第二次和/或第三次测试的参与者）和“完成者”（返回参加所有测试的参与者）中评估ε4对NINL测试表现的影响。ε4对退出率、NINL总分以及退出者和完成者的子分数均有影响。NINL总分是ε4参与者退出的一个预测指标。与非ε4退出者相比，ε4退出者的NINL得分较低。相反，ε4完成者的NINL得分高于非ε4完成者。因此，NINL测试可能是检测与年龄相关的认知障碍临床前迹象的有价值工具，特别是那些与ε4风险相关的迹象。
