Cardoso Ariel R, Queliconi Bruno B, Kowaltowski Alicia J
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, SP, Brazil.
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):832-8. doi: 10.1016/j.bbabio.2009.12.017. Epub 2010 Jan 5.
Mitochondria are the central coordinators of energy metabolism and alterations in their function and number have long been associated with metabolic disorders such as obesity, diabetes and hyperlipidemias. Since oxidative phosphorylation requires an electrochemical gradient across the inner mitochondrial membrane, ion channels in this membrane certainly must play an important role in the regulation of energy metabolism. However, in many experimental settings, the relationship between the activity of mitochondrial ion transport and metabolic disorders is still poorly understood. This review briefly summarizes some aspects of mitochondrial H+ transport (promoted by uncoupling proteins, UCPs), Ca2+ and K+ uniporters which may be determinant in metabolic disorders.
线粒体是能量代谢的核心协调者，其功能和数量的改变长期以来一直与肥胖、糖尿病和高脂血症等代谢紊乱相关。由于氧化磷酸化需要跨线粒体内膜的电化学梯度，因此该膜中的离子通道肯定在能量代谢调节中发挥重要作用。然而，在许多实验环境中，线粒体离子转运活性与代谢紊乱之间的关系仍未得到充分理解。本综述简要总结了线粒体H+转运（由解偶联蛋白，即UCPs促进）、Ca2+和K+单向转运体的某些方面，这些可能在代谢紊乱中起决定性作用。
