囊性纤维化患者丝状真菌恢复的流行情况和危险因素。
Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis.
机构信息
Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, 6th Floor, Baltimore, MD 21205, United States.
出版信息
J Cyst Fibros. 2010 Mar;9(2):110-6. doi: 10.1016/j.jcf.2009.11.010. Epub 2009 Dec 31.
Abstract
BACKGROUND
Filamentous fungi are frequently recovered from respiratory cultures of individuals with CF.
METHODS
A CF cohort database was utilized to determine filamentous fungal prevalence and risk factors.
RESULTS
The prevalence of filamentous fungal isolation increased from 2.0% in 1997 to 28.7% in 2007. The odds of isolating filamentous fungi during a quarter was greater in CF adults [p<0.001], during chronic oral antibiotic use [p=0.002] and increased with each 10% drop in FEV(1) percent predicted [p=0.005], while inhaled corticosteroids surprisingly decreased the likelihood [p=0.012]. The direction of these effects persisted after excluding individuals with ABPA. A sub-analysis determined older age [p=0.019] and use of inhaled antibiotics [p=0.011] were independent risk factors for onset of fungal colonization.
CONCLUSIONS
This study suggests that isolation of filamentous fungi in CF at JHH has increased and risk factors include older age, decreased lung function, and chronic oral antibiotics.
摘要
背景
丝状真菌常从 CF 患者的呼吸道培养物中分离出来。
方法
利用 CF 队列数据库来确定丝状真菌的流行率和危险因素。
结果
丝状真菌分离的流行率从 1997 年的 2.0%增加到 2007 年的 28.7%。在 CF 成人中[<0.001]，在慢性口服抗生素使用期间[=0.002]，每下降 10%的预计 FEV(1)百分比[=0.005]，分离丝状真菌的可能性更高，而吸入皮质类固醇则出乎意料地降低了这种可能性[=0.012]。在排除 ABPA 患者后，这些影响的方向仍然存在。一项亚分析确定，年龄较大[=0.019]和使用吸入抗生素[=0.011]是真菌定植开始的独立危险因素。
结论
本研究表明，JHH 的 CF 患者中丝状真菌的分离率有所增加，危险因素包括年龄较大、肺功能下降和慢性口服抗生素。
相似文献
1
Prevalence and risk factors for recovery of filamentous fungi in individuals with cystic fibrosis.囊性纤维化患者丝状真菌恢复的流行情况和危险因素。
J Cyst Fibros. 2010 Mar;9(2):110-6. doi: 10.1016/j.jcf.2009.11.010. Epub 2009 Dec 31.
2
Inhaled antibiotic use is associated with Scedosporium/Lomentospora species isolation in cystic fibrosis.吸入性抗生素的使用与囊性纤维化患者体内分离出的节菱孢霉/卷枝毛霉有关。
Pediatr Pulmonol. 2019 Feb;54(2):133-140. doi: 10.1002/ppul.24210. Epub 2018 Dec 14.
3
What is the clinical significance of filamentous fungi positive sputum cultures in patients with cystic fibrosis?在囊性纤维化患者中，丝状真菌阳性痰培养的临床意义是什么？
J Cyst Fibros. 2013 May;12(3):187-93. doi: 10.1016/j.jcf.2013.02.003. Epub 2013 Mar 13.
4
Risk factors for persistent Aspergillus respiratory isolation in cystic fibrosis.囊性纤维化患者中持续性烟曲霉呼吸道定植的危险因素。
J Cyst Fibros. 2018 Sep;17(5):624-630. doi: 10.1016/j.jcf.2018.01.008. Epub 2018 Feb 12.
5
A 16-year retrospective study on fungal prevalence and diversity in patients with cystic fibrosis: Candida dubliniensis was associated with a decline in lung function.一项关于囊性纤维化患者真菌流行率和多样性的 16 年回顾性研究：杜伦念珠菌与肺功能下降相关。
Int J Infect Dis. 2020 Jul;96:663-670. doi: 10.1016/j.ijid.2020.05.063. Epub 2020 May 22.
6
Prevalence and diversity of filamentous fungi in the airways of cystic fibrosis patients - A Dutch, multicentre study.囊性纤维化患者气道中丝状真菌的流行情况和多样性-一项荷兰多中心研究。
J Cyst Fibros. 2019 Mar;18(2):221-226. doi: 10.1016/j.jcf.2018.11.012. Epub 2018 Dec 1.
7
The clinical presentations of pulmonary aspergillosis in children with cystic fibrosis - preliminary report.囊性纤维化患儿肺曲霉病的临床表现——初步报告
Dev Period Med. 2015 Jan-Mar;19(1):66-79.
8
Frequency of fungi in respiratory samples from Turkish cystic fibrosis patients.土耳其囊性纤维化患者呼吸道样本中的真菌频率。
Mycoses. 2013 Mar;56(2):123-9. doi: 10.1111/j.1439-0507.2012.02221.x. Epub 2012 Jul 3.
9
Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis--a review.囊性纤维化患者呼吸道分泌物中丝状真菌的发生情况及相关性——综述
Med Mycol. 2009 Jun;47(4):387-97. doi: 10.1080/13693780802609604. Epub 2008 Dec 19.
10
Development of selective media for the isolation of yeasts and filamentous fungi from the sputum of adult patients with cystic fibrosis (CF).用于从成年囊性纤维化（CF）患者痰液中分离酵母和丝状真菌的选择性培养基的开发。
J Cyst Fibros. 2008 Nov;7(6):566-72. doi: 10.1016/j.jcf.2008.06.007. Epub 2008 Aug 23.
引用本文的文献
1
How to Assess Fungal Contamination of Indoor Air in Dwellings of Patients with Cystic Fibrosis?如何评估囊性纤维化患者住所内的室内空气真菌污染情况？
Mycopathologia. 2025 Jul 6;190(4):62. doi: 10.1007/s11046-025-00968-0.
2
Distinct airway mycobiome signature in patients with pulmonary hypertension and subgroups.肺动脉高压患者及其亚组中独特的气道真菌微生物群特征
BMC Med. 2025 Mar 10;23(1):148. doi: 10.1186/s12916-025-03982-7.
3
Increased NFAT and NFκB signalling contribute to the hyperinflammatory phenotype in response to Aspergillus fumigatus in a mouse model of cystic fibrosis.在囊性纤维化小鼠模型中，NFAT和NFκB信号通路增强导致对烟曲霉产生高炎症表型。
PLoS Pathog. 2025 Feb 4;21(2):e1012784. doi: 10.1371/journal.ppat.1012784. eCollection 2025 Feb.
4
The Real-World Effectiveness of Antifungals in People with Cystic Fibrosis and -Positive Cultures.抗真菌药物在囊性纤维化及培养结果呈阳性患者中的真实世界有效性
Ann Am Thorac Soc. 2025 Feb;22(2):193-199. doi: 10.1513/AnnalsATS.202312-1070OC.
5
Exploring the dynamics of mixed-species biofilms involving Candida spp. and bacteria in cystic fibrosis.探索涉及假丝酵母菌属和细菌的囊性纤维化混合物种生物膜的动态。
Arch Microbiol. 2024 May 11;206(6):255. doi: 10.1007/s00203-024-03967-9.
6
A cooperativity between virus and bacteria during respiratory infections.呼吸道感染期间病毒与细菌之间的协同作用。
Front Microbiol. 2023 Nov 30;14:1279159. doi: 10.3389/fmicb.2023.1279159. eCollection 2023.
7
Detection of Opportunistic Fungi from the Bronchoalveolar Lavage Specimens of Patients with Pulmonary Diseases.从肺部疾病患者支气管肺泡灌洗标本中检测机会性真菌。
Adv Biomed Res. 2023 Jul 20;12:176. doi: 10.4103/abr.abr_297_22. eCollection 2023.
8
In host evolution of Exophiala dermatitidis in cystic fibrosis lung micro-environment.在囊性纤维化肺部微环境中，皮炎外瓶霉的宿主进化。
G3 (Bethesda). 2023 Aug 9;13(8). doi: 10.1093/g3journal/jkad126.
9
Supernatants Disrupt Bronchial Epithelial Monolayers: Potential Role for Enhanced Invasion in Cystic Fibrosis.上清液破坏支气管上皮单层：在囊性纤维化中增强侵袭的潜在作用。
J Fungi (Basel). 2023 Apr 19;9(4):490. doi: 10.3390/jof9040490.
10
Upper respiratory tract mycobiome alterations in different kinds of pulmonary disease.不同类型肺部疾病中，上呼吸道真菌微生物群的改变
Front Microbiol. 2023 Mar 23;14:1117779. doi: 10.3389/fmicb.2023.1117779. eCollection 2023.
本文引用的文献
1
The effect of chronic infection with Aspergillus fumigatus on lung function and hospitalization in patients with cystic fibrosis.烟曲霉慢性感染对囊性纤维化患者肺功能和住院的影响。
Chest. 2010 Jan;137(1):171-6. doi: 10.1378/chest.09-1103. Epub 2009 Jun 30.
2
Occurrence and relevance of filamentous fungi in respiratory secretions of patients with cystic fibrosis--a review.囊性纤维化患者呼吸道分泌物中丝状真菌的发生情况及相关性——综述
Med Mycol. 2009 Jun;47(4):387-97. doi: 10.1080/13693780802609604. Epub 2008 Dec 19.
3
Relationship between inhaled corticosteroid therapy and rate of lung function decline in children with cystic fibrosis.吸入性皮质类固醇疗法与囊性纤维化患儿肺功能下降速率之间的关系。
J Pediatr. 2008 Dec;153(6):746-51. doi: 10.1016/j.jpeds.2008.07.010. Epub 2008 Aug 30.
4
Identification and management of unusual pathogens in cystic fibrosis.囊性纤维化中罕见病原体的识别与管理
J R Soc Med. 2008 Jul;101 Suppl 1(Suppl 1):S2-5. doi: 10.1258/jrsm.2008.s18002.
5
Invasive pulmonary aspergillosis in patients with COPD: a report of five cases and systematic review of the literature.慢性阻塞性肺疾病患者的侵袭性肺曲霉病：5例报告及文献系统综述
Chron Respir Dis. 2008;5(1):19-27. doi: 10.1177/1479972307085637.
6
Emergence of Scedosporium apiospermum in patients with cystic fibrosis.在囊性纤维化患者中出现的阿皮孢子菌。
Arch Dis Child. 2007 Jul;92(7):607. doi: 10.1136/adc.2007.119503.
7
Aspergillus bronchitis in cystic fibrosis.囊性纤维化中的曲霉性支气管炎
Chest. 2006 Jul;130(1):222-6. doi: 10.1378/chest.130.1.222.
8
Microbiology of airway disease in a cohort of patients with cystic fibrosis.一组囊性纤维化患者气道疾病的微生物学研究
BMC Infect Dis. 2006 Jan 11;6:4. doi: 10.1186/1471-2334-6-4.
9
Current approaches to diagnosis and treatment of invasive aspergillosis.侵袭性曲霉病的当前诊断与治疗方法。
Am J Respir Crit Care Med. 2006 Apr 1;173(7):707-17. doi: 10.1164/rccm.200505-727SO. Epub 2005 Dec 30.
10
Risk factors for allergic bronchopulmonary aspergillosis and sensitisation to Aspergillus fumigatus in patients with cystic fibrosis.囊性纤维化患者发生变应性支气管肺曲霉病及对烟曲霉致敏的危险因素。
Eur J Pediatr. 2005 Sep;164(9):577-82. doi: 10.1007/s00431-005-1701-4. Epub 2005 May 31.
Zotero 插件