Institute of Clinical Medicine, Institute of Biochemistry, National Yang-Ming University School of Medicine, Taipei, Taiwan.
Fertil Steril. 2010 Oct;94(5):1875-81. doi: 10.1016/j.fertnstert.2009.11.015. Epub 2010 Jan 4.
To evaluate the difference between uterine artery occlusion alone (UAO) and combined (UVO) with simultaneous blockage of anastomosis between the uterine and ovarian vessels in the management of women with myomas in a 3-year follow-up.
Case-control study.
University-associated hospital.
PATIENT(S): One hundred ten patients with uterine fibroids.
INTERVENTION(S): Forty-four patients underwent UAO and 66 patients UVO; patients were matched using a statistically generated selection of all UVOs performed during the same period.
MAIN OUTCOME MEASURE(S): Outcomes were assessed by comparing surgical parameters, immediate postoperative recovery, and therapeutic outcomes.
RESULT(S): During the 3-year follow-up, the majority of patients in both groups reported symptom relief (ranging from 61.5% to 84.6% in the UVO group and 31.6% to 77.3% in the UAO group, on the basis of different kinds of symptoms). However, symptom control seemed to be different between the two groups when the follow-up time was prolonged; for example, symptom control was better in the UVO group at the end of 3 years, especially for menorrhagia (76.5% vs. 34.5%). The fibroid size was smaller in the UVO group, resulting in a lower reintervention rate, compared with the UAO group (13.6% vs. 36.4%).
CONCLUSION(S): If UVO is used for uterine fibroids, the 3-year efficacy might be better than that with UAO. This finding is worthy of further investigation.
在 3 年随访中评估单纯子宫动脉阻断(UAO)与同时阻断子宫和卵巢血管吻合支(UVO)治疗子宫肌瘤患者的差异。
病例对照研究。
大学附属医院。
110 例子宫肌瘤患者。
44 例患者行 UAO,66 例患者行 UVO;采用统计学生成的方法对同期所有 UVOs 进行选择,以匹配患者。
通过比较手术参数、术后即刻恢复和治疗效果来评估结果。
在 3 年随访期间,两组大多数患者均报告症状缓解(基于不同类型的症状,在 UVO 组中为 61.5%至 84.6%,在 UAO 组中为 31.6%至 77.3%)。然而,随着随访时间的延长,两组之间的症状控制似乎有所不同;例如,在 3 年末,UVO 组的症状控制更好,尤其是月经过多(76.5%对 34.5%)。与 UAO 组相比,UVO 组的肌瘤体积较小,因此再次干预的比率较低(13.6%对 36.4%)。
如果 UVO 用于治疗子宫肌瘤,3 年的疗效可能优于 UAO。这一发现值得进一步研究。