Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Magn Reson Imaging. 2010 Apr;28(3):305-13. doi: 10.1016/j.mri.2009.11.003. Epub 2010 Jan 4.
To develop a method for estimating metabolite concentrations using phased-array coils and sensitivity-encoded (SENSE) magnetic resonance spectroscopic images (MRSI) of the human brain.
The method is based on the phantom replacement technique and uses receive coil sensitivity maps and body-coil loading factors to account for receive B(1) inhomogeneity and variable coil loading, respectively. Corrections for cerebrospinal fluid content from the MRSI voxel were also applied, and the total protocol scan time was less than 15 min. The method was applied to 10 normal human volunteers using a multislice 2D-MRSI sequence at 3 T, and seven different brain regions were quantified.
N-Acetyl aspartate (NAA) concentrations varied from 9.7 to 14.7 mM, creatine (Cr) varied from 6.6 to 10.6 mM and choline (Cho) varied from 1.6 to 3.0 mM, in good general agreement with prior literature values.
Quantitative SENSE-MRSI of the human brain is routinely possible using an adapted phantom-replacement technique. The method may also be applied to other MRSI techniques, including conventional phase encoding, with phased-array receiver coils, provided that coil sensitivity profiles can be measured.
开发一种使用相控阵线圈和人体脑部的灵敏度编码（SENSE）磁共振波谱成像（MRSI）估计代谢物浓度的方法。
该方法基于幻影替换技术，使用接收线圈灵敏度图和体线圈加载因子分别来考虑接收 B(1)不均匀性和可变的线圈加载。还对 MRSI 体素中的脑脊液含量进行了校正，并且总协议扫描时间小于 15 分钟。该方法应用于 10 名正常志愿者，使用 3T 的多切片 2D-MRSI 序列，并对 7 个不同的脑区进行了定量。
N-乙酰天冬氨酸（NAA）浓度在 9.7 至 14.7mM 之间变化，肌酸（Cr）浓度在 6.6 至 10.6mM 之间变化，胆碱（Cho）浓度在 1.6 至 3.0mM 之间变化，总体上与先前的文献值一致。
使用适应性幻影替换技术，常规进行人体脑部的定量 SENSE-MRSI 是可行的。该方法也可应用于其他 MRSI 技术，包括常规相位编码，使用相控阵接收线圈，前提是可以测量线圈灵敏度图。
