Cancer Care Research Centre (CCRC), University of Stirling, Stirling, Scotland, UK.
Hormones (Athens). 2009 Oct-Dec;8(4):232-48. doi: 10.14310/horm.2002.1239.
Sleep is an essential ubiquitous biological process, a periodical state of quiescence in which there is minimal processing of sensory information and no interaction with conspecifics or the environment. Despite relevant research on sleep structure and testing of numerous endogenous sleep-affecting chemicals, questions as to the precise mechanisms and functions of sleep remain without satisfactory responses. The purpose of this review is to report on current evidence as regards the effect of several endogenous and exogenous hormones, hormonal agents, and neuropeptides on sleep onset or wake process, when administered in humans in specific doses and via different routes. The actions of several peptides are presented in detail. Some of them (growth hormone releasing hormone, ghrelin, galanin, neuropeptide Y) seem to promote sleep, whereas others (corticotropin, somatostatin) impair its continuity.
睡眠是一种基本的、普遍存在的生物过程，是一种周期性的静止状态，在此期间，感觉信息的处理最少，与同类或环境没有互动。尽管对睡眠结构进行了相关研究，并对许多内源性影响睡眠的化学物质进行了测试，但关于睡眠的确切机制和功能的问题仍然没有得到令人满意的回答。本综述的目的是报告当前关于几种内源性和外源性激素、激素制剂和神经肽对睡眠开始或觉醒过程的影响的证据，当以特定剂量和不同途径在人体中给药时。详细介绍了几种肽的作用。其中一些（生长激素释放激素、胃饥饿素、甘丙肽、神经肽 Y）似乎能促进睡眠，而另一些（促肾上腺皮质激素、生长抑素）则会破坏睡眠的连续性。
