Rebhun Robert B, Thamm Douglas H
Animal Cancer Center and Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 300 West Drake Road, Fort Collins, Colorado 80523, USA.
J Am Anim Hosp Assoc. 2010 Jan-Feb;46(1):20-30. doi: 10.5326/0460020.
Despite the clinical recognition of multiple distinct types of neoplasia in individual dogs, a detailed description of such cases has not recently been published. Canine oncology cases that were diagnosed with multiple, confirmed, distinct malignancies were prospectively collected for analysis. Approximately 3% of 1722 dogs that were presented to the oncology service at the Colorado State University Veterinary Medical Center were diagnosed with multiple distinct primary tumors. No significant breed or sex predisposition was apparent. Dogs with mast cell tumor, malignant melanoma, and thyroid carcinoma were significantly overrepresented and thus more likely to be diagnosed with multiple tumor types. These findings emphasize the importance of thorough, whole-body evaluation for dogs presented with mast cell tumor, malignant melanoma, and thyroid carcinoma. Furthermore, because approximately 33% of dogs that were presented with thyroid tumors were found to have additional distinct tumors, complete staging is justified in all dogs presented with thyroid tumors.
尽管临床上已认识到个别犬存在多种不同类型的肿瘤，但近期尚未发表对此类病例的详细描述。前瞻性收集了经诊断患有多种确诊的不同恶性肿瘤的犬类肿瘤病例进行分析。在科罗拉多州立大学兽医学院医疗中心接受肿瘤治疗的1722只犬中，约3%被诊断患有多种不同的原发性肿瘤。未发现明显的品种或性别易感性。患有肥大细胞瘤、恶性黑色素瘤和甲状腺癌的犬明显比例过高，因此更有可能被诊断出患有多种肿瘤类型。这些发现强调了对患有肥大细胞瘤、恶性黑色素瘤和甲状腺癌的犬进行全面全身评估的重要性。此外，由于约33%患有甲状腺肿瘤的犬被发现还患有其他不同的肿瘤，因此对所有患有甲状腺肿瘤的犬进行全面分期是合理的。
