Wucherer Katja L, Wilke Vicki
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1352 Boyd Avenue, St. Paul, Minnesota 55108, USA.
J Am Anim Hosp Assoc. 2010 Jul-Aug;46(4):249-54. doi: 10.5326/0460249.
The goal of this study was to update the descriptive statistics of thyroid cancer by using data from multiple institutions collected through the Veterinary Medical Database (VMDB). Information was collected and reported from cases of canine thyroid cancer submitted to the VMDB between January 1, 1995 and December 31, 2005. Odds ratio (OR) analysis was performed on breeds that had > or =3% of the total number of dogs with thyroid cancer; ORs for each age category were also determined. Thyroid cancer represented 1.1% of all neoplasms during the time period of interest. Golden retrievers, beagles, and Siberian huskies all had significantly increased ORs for developing thyroid cancer. No sex predisposition was evident, but dogs between 10 and 15 years of age had a significantly increased chance of developing thyroid disease. Carcinomas and adenocarcinomas represented 90% of thyroid cancers, while adenomas represented 9.3%. Thyroid carcinoma and adenocarcinoma continue to be uncommon in our canine population. Older dogs are still more commonly affected, and this study is in agreement with previous studies that golden retrievers and beagles are overrepresented. A new finding is that Siberian huskies are also overrepresented. Carcinomas represent a much higher proportion of thyroid cancers than previously reported, and adenomas are likely incidental findings on necropsy. Thyroid cancer should be high on the list of differentials for a neck mass in older, large-breed dogs, as they make up 1.1% of the cancer cases reported. The overwhelming majority of thyroid cancers are carcinomas, and they are most common in golden retrievers, beagles, and Siberian huskies.
本研究的目的是利用通过兽医医学数据库（VMDB）收集的来自多个机构的数据，更新甲状腺癌的描述性统计数据。收集并报告了1995年1月1日至2005年12月31日期间提交至VMDB的犬甲状腺癌病例信息。对患甲状腺癌犬只总数占比≥3%的品种进行了优势比（OR）分析；还确定了各年龄组的OR值。在所关注的时间段内，甲状腺癌占所有肿瘤的1.1%。金毛寻回犬、比格犬和西伯利亚哈士奇患甲状腺癌的OR值均显著升高。未发现明显的性别倾向，但10至15岁的犬患甲状腺疾病的几率显著增加。癌和腺癌占甲状腺癌的90%，而腺瘤占9.3%。甲状腺癌和腺癌在我们的犬类群体中仍然不常见。老年犬仍然更易受影响，并且本研究与之前的研究一致，即金毛寻回犬和比格犬的占比过高。一个新发现是西伯利亚哈士奇的占比也过高。癌在甲状腺癌中所占比例比之前报道的要高得多，腺瘤很可能是尸检时的偶然发现。对于老年大型犬颈部肿块，甲状腺癌应列为鉴别诊断的重要考虑因素，因为它们占报告的癌症病例的1.1%。绝大多数甲状腺癌是癌，它们在金毛寻回犬、比格犬和西伯利亚哈士奇中最为常见。
