Harden C L, Rosenbaum D H, Daras M
Department of Neurology, New York Medical College/Metropolitan Hospital, NY 10029.
Epilepsia. 1991 Mar-Apr;32(2):215-20. doi: 10.1111/j.1528-1157.1991.tb05247.x.
Seizures are common in hyperglycemia and are often the first manifestation, particularly in nonketotic hyperglycemia (NKH). Published reports emphasize partial motor seizures almost exclusively. In a 3-year period, we observed three patients in whom occipital seizures, documented by ictal EEG recording, were the initial symptom of hyperglycemia. One patient was mildly ketotic at first. Seizures were visual in two patients and visual and adversive in the third. Seizures regressed with correction of abnormal glucose levels and did not recur during follow-up of less than or equal to 1 year despite discontinuation of antiepileptic drugs (AEDs) in two. Computed tomography (CT) scans did not show correlative abnormalities. Although published reports suggest that frontal lobe structures are particularly susceptible to the epileptogenic effects of NKH, our experience indicates that in NKH epileptic foci may originate in other cortical areas, such as occipital.
癫痫发作在高血糖症中很常见，且往往是首发表现，尤其是在非酮症高血糖症（NKH）中。已发表的报告几乎只强调部分运动性癫痫发作。在3年期间，我们观察到3例患者，其枕叶癫痫发作经发作期脑电图记录证实，是高血糖症的初始症状。1例患者起初有轻度酮症。2例患者的癫痫发作表现为视觉症状，第3例患者则为视觉和转位症状。随着血糖异常水平的纠正，癫痫发作得到缓解，在随访时间小于或等于1年期间，尽管有2例患者停用了抗癫痫药物（AEDs），癫痫发作也未复发。计算机断层扫描（CT）未显示相关异常。尽管已发表的报告表明额叶结构对NKH的致痫作用特别敏感，但我们的经验表明，在NKH中癫痫病灶可能起源于其他皮质区域，如枕叶。
