Innes A Micheil, Seshia Molly M, Prasad Chitra, Al Saif Saif, Friesen Frank R, Chudley Albert E, Reed Martin, Dilling Louise A, Haworth James C, Greenberg Cheryl R
Departments of Pediatrics and Child Health.
Paediatr Child Health. 2002 Sep;7(7):455-8. doi: 10.1093/pch/7.7.455.
The cases of four newborn infants with congenital rickets are reported. All infants were native Canadian: three were Cree and one was Inuit. One had a narrow chest and pulmonary hypoplasia, two had clinical and radiological signs of rickets with craniotabes, thickened wrists, and prominent costochondral junctions, and one had perinatal asphyxia and hydrops. All had hypocalcemia, hypophosphatemia and secondary hyperparathyroidism. Serum 25-hydroxyvitamin D levels were low in three of the infants. The four mothers had evidence of vitamin D deficiency. All infants recovered following treatment with 5000 IU oral vitamin D daily.
报告了4例先天性佝偻病新生儿病例。所有婴儿均为加拿大原住民：3例是克里族，1例是因纽特族。1例有胸廓狭窄和肺发育不全，2例有佝偻病的临床和放射学体征，如颅骨软化、手腕增粗和肋软骨连接处突出，1例有围产期窒息和水肿。所有患儿均有低钙血症、低磷血症和继发性甲状旁腺功能亢进。3例婴儿血清25-羟维生素D水平较低。4位母亲均有维生素D缺乏的证据。所有婴儿每日口服5000 IU维生素D治疗后均康复。
