Brooke O G, Brown I R, Cleeve H J, Sood A
Br J Obstet Gynaecol. 1981 Jan;88(1):18-26. doi: 10.1111/j.1471-0528.1981.tb00931.x.
Vitamin D nutrition in pregnancy was investigated in 115 Asian women living in London, and in 50 of their newborn infants. Mean serum 25-hydroxy cholecalciferal (25-OHD) concentration at the beginning of the last trimester was 20.2 nmol/l, and fell to 16.0 nmol/1 post partum. Thirty-six per cent of the women post partum and 32 per cent of the infants had undetectable 25-OHD concentrations (less than 3 nmol/l). Such low values are commonly associated with osteomalacia and rickets. The bone isoenzyme of alkaline phosphatase was elevated in 20 per cent of the women post partum, and in 50 per cent of the infants, indicating the presence of sub-clinical bone disease. Five infants had symptomatic hypocalcaemia. Vitamin D deficiency was most likely to occur in Pakistanis, Hindu Indians and East African Asians, and in vegetarians. All British Asians should receive supplementary Vitamin D during pregnancy.
对居住在伦敦的115名亚洲女性及其50名新生儿的孕期维生素D营养状况进行了调查。妊娠晚期开始时血清25-羟胆钙化醇（25-OHD）的平均浓度为20.2纳摩尔/升，产后降至16.0纳摩尔/升。36%的产后女性和32%的婴儿25-OHD浓度检测不到（低于3纳摩尔/升）。如此低的值通常与骨软化症和佝偻病有关。20%的产后女性和50%的婴儿碱性磷酸酶的骨同工酶升高，表明存在亚临床骨病。5名婴儿出现有症状的低钙血症。维生素D缺乏最容易发生在巴基斯坦人、印度教印度人和东非亚洲人以及素食者身上。所有英国亚洲女性在孕期都应补充维生素D。
