Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Korea.
Psychiatry Investig. 2009 Jun;6(2):72-7. doi: 10.4306/pi.2009.6.2.72. Epub 2009 Jun 30.
Prefrontal and cerebellar abnormalities have been associated with higher cognitive deficits in schizophrenia. The current study aimed to show whether or not schizophrenic patients with fronto-cerebellar functional abnormalities show more anhedonia or ambivalence.
Regional cerebral metabolic activity was measured using fluoro-D-glucose positron emission tomography and was compared between 24 patients with chronic schizophrenia and 22 healthy normal volunteers. The existence of regional prefrontal hypofunction and regional cerebellar hyperfunction was investigated in each patient. Demographic and clinical variables including the emotional self-report scales were compared between the subgroups of the patients categorized according to the existence and the absence of the regional dysfunctions.
Comparisons between each patient and the total normal controls revealed that 14 of the total twenty-four patients had regional hypofrontal functions, whereas 11 patients had regional hypercerebellar functions. Patients with prefrontal hypofunction showed more severe anhedonia than those without prefrontal hypofunction, whereas patients with cerebellar hyperfunction compared to those without cerebellar hyperfunction had more severe ambivalence.
It seems that fronto-cerebellar abnormalities may be associated with cardinal emotional features of schizophrenia, such as anhedonia and ambivalence.
前额叶和小脑异常与精神分裂症患者的较高认知缺陷有关。本研究旨在表明是否存在前额-小脑功能异常的精神分裂症患者表现出更多的快感缺失或矛盾心理。
使用氟-D-葡萄糖正电子发射断层扫描测量局部脑代谢活性，并将 24 名慢性精神分裂症患者和 22 名健康正常志愿者进行比较。在每位患者中研究了区域性前额叶功能低下和区域性小脑功能亢进的存在。根据区域功能障碍的存在与否，将患者分为亚组，并对人口统计学和临床变量（包括情绪自我报告量表）进行比较。
将每个患者与总正常对照组进行比较，发现 24 名患者中有 14 名存在区域性前额叶功能低下，而 11 名患者存在区域性小脑功能亢进。与没有前额叶功能低下的患者相比，前额叶功能低下的患者表现出更严重的快感缺失，而与没有小脑功能亢进的患者相比，小脑功能亢进的患者表现出更严重的矛盾心理。
前额叶-小脑异常可能与精神分裂症的主要情感特征（如快感缺失和矛盾心理）有关。
