Setty C Mallikarjuna, Prasad D V K, Gupta V R M, Sa B
Department of Pharmaceutics, N.E.T. Pharmacy College, Raichur-584 103, India.
Indian J Pharm Sci. 2008 Mar-Apr;70(2):180-5. doi: 10.4103/0250-474X.41452.
Aceclofenac, a non-steroidal antiinflammatory drug, is used for posttraumatic pain and rheumatoid arthritis. Aceclofenac fast-dispersible tablets have been prepared by direct compression method. Effect of superdisintegrants (such as, croscarmellose sodium, sodium starch glycolate and crospovidone) on wetting time, disintegration time, drug content, in vitro release and stability parameters has been studied. Disintegration time and dissolution parameters (t(50%) and t(80%)) decreased with increase in the level of croscarmellose sodium. Where as, disintegration time and dissolution parameters increased with increase in the level of sodium starch glycolate in tablets. However, the disintegration time values did not reflect in the dissolution parameter values of crospovidone tablets and release was dependent on the aggregate size in the dissolution medium. Stability studies indicated that tablets containing superdisintegrants were sensitive to high humidity conditions. It is concluded that fast-dispersible aceclofenac tablets could be prepared by direct compression using superdisintegrants.
醋氯芬酸是一种非甾体抗炎药，用于治疗创伤后疼痛和类风湿性关节炎。醋氯芬酸速溶片已通过直接压片法制备。研究了超级崩解剂（如交联羧甲基纤维素钠、淀粉乙醇酸钠和交联聚维酮）对润湿时间、崩解时间、药物含量、体外释放和稳定性参数的影响。随着交联羧甲基纤维素钠水平的增加，崩解时间和溶出参数（t(50%)和t(80%)）降低。而片剂中淀粉乙醇酸钠水平增加时，崩解时间和溶出参数增加。然而，交联聚维酮片的崩解时间值并未反映在溶出参数值中，释放取决于溶出介质中的聚集体大小。稳定性研究表明，含有超级崩解剂的片剂对高湿度条件敏感。得出结论认为，使用超级崩解剂通过直接压片可制备醋氯芬酸速溶片。
