Wadher S J, Pathankar P R, Puranik Manisha, Ganjiwale R O, Yeole P G
Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha- 442 001, India.
Indian J Pharm Sci. 2008 May-Jun;70(3):393-5. doi: 10.4103/0250-474X.43014.
Two simple, accurate, rapid and economical spectrophotometric methods have been developed for the simultaneous determination of paracetamol and metoclopramide hydrochloride from tablet dosage form. The first method developed employs formation and solving simultaneous equations using 248.6 nm and 275.6 nm as two wavelengths for formation of equations. Second method is absorbance ratio in which wavelengths selected were 265.6 nm as isoabsorptive point and 275.6 nm as lambdamax of paracetamol. Both the drugs and their mixtures obey Beer-Lamberts law at selected wavelengths at given concentration range. The methods have been validated statistically and by recovery studies. The results of analysis have been validated statistically and by recovery studies.
已开发出两种简单、准确、快速且经济的分光光度法，用于同时测定片剂剂型中的对乙酰氨基酚和盐酸甲氧氯普胺。所开发的第一种方法利用在248.6 nm和275.6 nm两个波长处形成并求解联立方程来构建方程。第二种方法是吸光度比值法，所选波长为265.6 nm作为等吸收点，275.6 nm作为对乙酰氨基酚的最大吸收波长。在给定浓度范围内，两种药物及其混合物在选定波长下均符合比尔-朗伯定律。这些方法已通过统计学验证和回收率研究进行了验证。分析结果已通过统计学验证和回收率研究进行了验证。
