Bryson S M, McGovern E M, Gilbert L M
J Clin Hosp Pharm. 1984 Sep;9(3):263-6. doi: 10.1111/j.1365-2710.1984.tb01086.x.
High-dose metoclopramide has found an established place in the prophylaxis of nausea and vomiting which may be induced by cancer chemotherapy. A simple reliable high pressure liquid chromatographic technique for the measurement of this drug in serum has been developed and evaluated. The methodology will find application in the study of metoclopramide pharmacokinetics and in the monitoring of high-dose metoclopramide therapy in individual patients with neoplastic disease.
大剂量甲氧氯普胺已在预防癌症化疗所致恶心和呕吐方面确立了地位。现已开发并评估了一种简单可靠的高压液相色谱技术用于测定血清中的该药物。该方法将应用于甲氧氯普胺药代动力学研究以及对患有肿瘤疾病的个体患者进行大剂量甲氧氯普胺治疗的监测。
