Gajbhiye V, Kumar P Vijayaraj, Sharma A, Agarwal A, Asthana A, Jain N K
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar-470 003, India.
Indian J Pharm Sci. 2008 Jul-Aug;70(4):431-9. doi: 10.4103/0250-474X.44589.
Transdermal route is an evolving panorama in novel drug deliverance and with oral route they proffer immense potential. Most recently there is hastening in approaches for delivering bioactives via these routes, amongst them revolution has been made by dendrimers. Encapsulation and conjugation of bioactives with these virus sized robots have shown immense employment for delivery of hydrophobic and labile remedies. Transport of these nano-cruises from corner to corner of skin and through epithelial hurdle of gastrointestinal tract depends upon dendrimer characteristics. An improved thoughtful of these characteristics is an obligation for their use in these rambling fields. These characteristics embrace generation size, molecular weight, surface charge, incubation time and concentration. This context demarcates the imperative role of dendrimers in transdermal and oral drug delivery. This review also highlights concerning mechanism of convey of nanoarrays via epithelial hurdle of GIT.
透皮途径是新型药物递送领域中不断发展的一个方面，与口服途径一样具有巨大潜力。最近，通过这些途径递送生物活性物质的方法发展迅速，其中树枝状大分子带来了变革。生物活性物质与这些病毒大小的机器人的包封和缀合在递送疏水和不稳定药物方面显示出巨大的应用价值。这些纳米载体在皮肤各处以及通过胃肠道上皮屏障的转运取决于树枝状大分子的特性。更好地了解这些特性是它们在这些广泛领域中应用的必要条件。这些特性包括代数大小、分子量、表面电荷、孵育时间和浓度。本文阐述了树枝状大分子在透皮和口服药物递送中的重要作用。本综述还强调了纳米阵列通过胃肠道上皮屏障的转运机制。
