Department of Obstetrics and Gynaecology, The University of Western Ontario, London, Ontario, Canada.
PLoS One. 2009 Dec 31;4(12):e8530. doi: 10.1371/journal.pone.0008530.
SNAI1 and SNAI2 are transcription factors that initiate Epithelial-to-Mesenchymal cell transitions throughout development and in cancer metastasis. Here we show novel expression of SNAI1 and SNAI2 throughout mouse preimplantation development revealing asymmetrical localization of both SNAI1 and SNAI2 in individual blastomeres beginning at the 2-cell stage through to the 8-cell stage where SNAI1 and SNAI2 are then only detected in outer cells and not inner cells of the blastocyst. This study implicates SNAI1 and SNAI2 in the lineage segregation of the trophectoderm and inner cell mass, and provides new insight into these oncogenes.
SNAI1 和 SNAI2 是转录因子，在整个发育过程中以及癌症转移过程中启动上皮细胞向间充质细胞的转变。在这里，我们在整个小鼠着床前发育过程中展示了 SNAI1 和 SNAI2 的新表达，揭示了 SNAI1 和 SNAI2 在单个卵裂球中的不对称定位，从 2 细胞期开始，一直到 8 细胞期，此时 SNAI1 和 SNAI2 仅在外细胞中检测到，而不在囊胚的内细胞中。这项研究表明 SNAI1 和 SNAI2 参与了滋养外胚层和内细胞团的谱系分离，并为这些癌基因提供了新的见解。
