快速流变学筛选以确定生物材料水凝胶化的条件。
Rapid rheological screening to identify conditions of biomaterial hydrogelation.
作者信息
Schultz Kelly M, Baldwin Aaron D, Kiick Kristi L, Furst Eric M
机构信息
Department of Chemical Engineering and Center for Molecular and Engineering Thermodynamics, University of Delaware, 150 Academy St., Newark, DE 19716, USA.
出版信息
Soft Matter. 2009 Jan 1;5(4):740-742. doi: 10.1039/b818178k.
Abstract
Hydrogels engineered for biomedical applications consist of numerous components, each of which can affect the material assembly and final mechanical properties. We present methods that rapidly generate rheological libraries to identify regimes of hydrogel assembly in a large composition parameter space. This method conserves both material and time, and leads to critical insight into assembly mechanisms and mechanics, which can then be used for further materials development and optimization.
摘要
为生物医学应用而设计的水凝胶由众多成分组成，其中每一种成分都会影响材料的组装和最终的机械性能。我们提出了快速生成流变学库的方法，以在大的成分参数空间中识别水凝胶组装的状态。这种方法既节省材料又节省时间，并能深入洞察组装机制和力学性能，进而可用于进一步的材料开发和优化。
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