Lee K Y, Peters M C, Anderson K W, Mooney D J
Department of Biologic & Materials Sciences, University of Michigan, Ann Arbor 48109, USA.
Nature. 2000;408(6815):998-1000. doi: 10.1038/35050141.
Polymeric matrices can be used to grow new tissues and organs, and the delivery of growth factors from these matrices is one method to regenerate tissues. A problem with engineering tissues that exist in a mechanically dynamic environment, such as bone, muscle and blood vessels, is that most drug delivery systems have been designed to operate under static conditions. We thought that polymeric matrices, which release growth factors in response to mechanical signals, might provide a new approach to guide tissue formation in mechanically stressed environments. Critical design features for this type of system include the ability to undergo repeated deformation, and a reversible binding of the protein growth factors to polymeric matrices to allow for responses to repeated stimuli. Here we report a model delivery system that can respond to mechanical signalling and upregulate the release of a growth factor to promote blood vessel formation. This approach may find a number of applications, including regeneration and engineering of new tissues and more general drug-delivery applications.
聚合物基质可用于培育新的组织和器官，从这些基质中递送生长因子是组织再生的一种方法。对于存在于机械动态环境中的组织（如骨骼、肌肉和血管）进行工程化处理时，一个问题是大多数药物递送系统都是设计用于在静态条件下运行的。我们认为，能响应机械信号释放生长因子的聚合物基质，可能为在机械应力环境中引导组织形成提供一种新方法。这类系统的关键设计特征包括能够经受反复变形，以及蛋白质生长因子与聚合物基质的可逆结合，以便对反复刺激作出反应。在此，我们报告一种模型递送系统，它能够响应机械信号并上调生长因子的释放以促进血管形成。这种方法可能有许多应用，包括新组织的再生和工程化处理以及更广泛的药物递送应用。
