氰基肟类作为有效且具选择性的共结晶剂。
Cyanoximes as effective and selective co-crystallizing agents.
作者信息
Aakeröy Christer B, Salmon Debra J, Smith Michelle M, Desper John
机构信息
Department of Chemistry, Kansas State University, Manhattan, KS, 66506,
出版信息
CrystEngComm. 2009 Jan 1;11(3):439-443. doi: 10.1039/b811322j.
Abstract
The ability of cyanoxime-based synthons to act as versatile synthetic tools for the construction of co-crystals is demonstrated through the preparation and structural characterization of seven co-crystals. Cyanoximes can bind effectively to both five-membered and six-membered N-heterocyclic hydrogen-bond acceptors, and they also display selectivity towards the best acceptor (as determined using semi-empirical AM1 calculations) in ditopic compounds.
摘要
通过七种共晶体的制备和结构表征，证明了基于氰基肟的合成子作为构建共晶体的通用合成工具的能力。氰基肟可以有效地与五元及六元氮杂环氢键受体结合，并且在双位点化合物中，它们还对最佳受体表现出选择性（通过半经验AM1计算确定）。
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