来自荚膜红假单胞菌的抗病毒物质顺式 vaccenic 酸以及不饱和脂肪酸和相关醇类对 T5 噬菌体的灭活作用。

Inactivation of T5 phage by cis-vaccenic acid, an antivirus substance from Rhodopseudomonas capsulata, and by unsaturated fatty acids and related alcohols.

作者信息

Hirotani H, Ohigashi H, Kobayashi M, Koshimizu K, Takahashi E

机构信息

Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University, Japan.

出版信息

FEMS Microbiol Lett. 1991 Jan 1;61(1):13-7. doi: 10.1016/0378-1097(91)90006-v.

DOI:10.1016/0378-1097(91)90006-v

PMID:2004693

Abstract

The antiviral extract from Rhodopseudomonas capsulata was purified and the predominant active component was defined as cis-vaccenic acid (Cl-8:1 delta 11) by gas-liquid chromatography and gas chromatography-mass spectrometry analyses. Antiviral activities of unsaturated fatty acids and related alcohols against T5 phage were also tested. Among them, linoelaidic acid, oleic acid, and petroselenyl alcohol inactivated 98%, 53%, 67% of T5 phage at the concentration of 50 micrograms/ml, respectively.

摘要

对荚膜红假单胞菌的抗病毒提取物进行了纯化，并通过气液色谱和气相色谱-质谱分析将主要活性成分确定为顺式- vaccenic酸（Cl-8:1 δ 11）。还测试了不饱和脂肪酸和相关醇类对T5噬菌体的抗病毒活性。其中，亚油酸、油酸和岩芹醇在浓度为50微克/毫升时分别使98%、53%、67%的T5噬菌体失活。