脑脊液中选择耐恩夫韦肽的 HIV-1 后治疗失败。
Therapy failure following selection of enfuvirtide-resistant HIV-1 in cerebrospinal fluid.
机构信息
Department of Virology, University Medical Center Utrecht, G04.614 Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
出版信息
Clin Infect Dis. 2010 Feb 1;50(3):387-90. doi: 10.1086/649874.
DOI:10.1086/649874
PMID:20047481
Abstract
We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.
摘要
我们报告了人类免疫缺陷病毒 1 型在脑脊液中对恩夫韦肽产生耐药性，导致随后血浆中病毒抑制作用丧失。本病例报告强调了进入抑制剂进入中枢神经系统时低水平穿透的潜在危险。
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