Department of Virology, University Medical Center Utrecht, G04.614 Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
Clin Infect Dis. 2010 Feb 1;50(3):387-90. doi: 10.1086/649874.
We report the selection of enfuvirtide-resistant human immunodeficiency virus type 1 in cerebrospinal fluid, resulting in subsequent loss of viral suppression in the plasma. This case report emphasizes the potential danger of low-level penetration of entry inhibitors into the central nervous system.
我们报告了人类免疫缺陷病毒 1 型在脑脊液中对恩夫韦肽产生耐药性，导致随后血浆中病毒抑制作用丧失。本病例报告强调了进入抑制剂进入中枢神经系统时低水平穿透的潜在危险。
